Targets of Signal Transduction Pathways in Melanoma
نویسندگان
چکیده
منابع مشابه
Signal transduction pathways in sarcoma as targets for therapeutic intervention.
Investigations into the molecular alterations in sarcomas have made substantial progress during the past decade. Classical linkage analysis and the direct sequencing of chromosomal translocation fusions have identified candidate genes in many different sarcomas. A large group of these genes participate in signal transduction pathways and represent potential sites of disease intervention with ta...
متن کاملSignal Transduction Pathways in Breast Cancer – Drug Targets and Challenges
Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death in females worldwide [1]. Over 1.1 million cases of breast cancer are diagnosed across the world each year, compared with about 500,000 cases in 1975. This represents about 10% of all new cancer cases and 23% of all female cancers [2-3]. An annual prevalence of more than 4.4 million cases of breast cance...
متن کاملIntracellular signal transduction pathways as targets for neurotoxicants.
The multiple cascades of signal transduction pathways that lead from receptors on the cell membrane to the nucleus, thus translating extracellular signals into changes in gene expression, may represent important targets for neurotoxic compounds. Among the biochemical steps and pathways that have been investigated are the metabolism of cyclic nucleotides, the formation of nitric oxide, the metab...
متن کاملSignal transduction pathways: targets for green and black tea polyphenols.
Tea is one of the most popular beverages consumed in the world and has been demonstrated to have anti-cancer activity in animal models. Research findings suggest that the polyphenolic compounds, (-)-epigallocatechin-3-gallate found primarily in green tea, and theaflavin-3,3'-digallate, a major component of black tea, are the two most effective anti-cancer factors found in tea. Several mechanism...
متن کاملEngineering Signal Transduction Pathways
Cells respond to their environment by sensing signals and translating them into changes in gene expression. In recent years, synthetic networks have been designed in both prokaryotic and eukaryotic systems to create new functionalities and for specific applications. In this review, we discuss the challenges associated with engineering signal transduction pathways. Furthermore, we address advant...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2006
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.20.5.a852-d